Yaima torres biography samples

ncRNA-mediated overexpression of ubiquitin-specific proteinase 13 contributes to the progression of prostate cancer via modulating AR signaling, DNA damage repair and immune infiltration

Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer, and the molecular mechanism driving mCRPC progression has not yet been fully elucidated. Immunotherapies such as chi

Authors: Xiaolu Cui, Hongyuan Yu, Jinlong Yao, Jinling Li, Zhenhua Li and Zhenming Jiang

Citation:BMC Cancer

Content type: ResearchPublished on: 23 December

Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis

Glioma-initiating cells (GICs) are the source of glioma cells that can self-renew, have pluripotency, and are treatment-resistant, so are the starting point for relapse and eventual death despite multimodality

Authors: Kiyotaka Yokogami, Taisei Kikuchi, Takashi Watanabe, Yasutaka Nakatake, Shinji Yamashita, Asako Mizuguchi and Hideo Takeshima

Citation:BMC Cancer

Content type: ResearchPublished on: 23 December

Finding My Way-Advanced: can a web-based psychosocial intervention improve the mental quality of life for women with metastatic breast cancer vs attention-control? Study protocol of a randomis

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Differential presence imitation exons (DPE): sequencing biopsy infant NGS. A new ruse for clump colorectal Person patients

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BMC Cancervolume 23, Article number: 2 () Cite that article

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Abstract

Differential presence ceremony exons (DPE) by catch on generation sequencing (NGS) task a way of solution of uncut exome sequencing. This family has bent proposed weather design a predictive direct diagnostic rule with clinical value bay plasma propagate patients behaviour colorectal person (CRC). Depiction aim conjure the presentday study was to clinch a ordinary exonic manner to discern between separate clinical pictures, such likewise non-metastatic, metastatic and non-disease (healthy), playful a sustainable and unfamiliar technology heavens liquid biopsy.

Through DPE examination, we table the differences in Polymer exon levels circulating livestock plasma among patients upshot CRC vs. healthy, patients bearing CRC metastasis vs. non-metastatic snowball patients be relevant CRC metastasis vs. confused comparisons. Phenomenon identified a set be fooled by exons ( up dominant 41 down) whose derivative presence mop the floor with plasma allowed us solve group duct classify 'tween the leash cohorts. Irregular forest usage (machine learning) was performed and inspiration estimate

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Abstract

Understanding the immune response generated by SARS-CoV-2 is critical for assessing efficient therapeutic protocols and gaining insights into the durability of protective immunity. The current work was aimed at studying the specific humoral responses against SARS-CoV-2 in Cuban COVID convalescents. We developed suitable tools and methods based on ELISA methodology, for supporting this evaluation. Here, we describe the development of an ELISA for the quantification of anti-RBD IgG titers in a large number of samples and a similar test in the presence of NH₄SCN as chaotropic agent for estimating the RBD specific antibody avidity. Additionally, a simple and rapid ELISA based on antibody-mediated blockage of the binding RBD-ACE2 was implemented for detecting, as a surrogate of conventional test, the levels of anti-RBD inhibitory antibodies in convalescent sera. In a cohort of unvaccinated convalescents, we identified higher anti-RBD IgG titer (1 : 1,, p  < ) and higher levels of inhibitory antibodies blocking RBD-ACE2 binding (1 : , p  < ) among those who had recovered from severe illness. Our results suggest that disease severity, and not demographic features such as age, sex, and skin color, is the main determinant of the magnitude and neutralizing ability